Содержание курса
1. Introduction
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1.1
What is CAST?
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1.2
What can we learn from our genomes?
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1.3
What are genetic variation and genetic diversity?
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1.4
What is precision medicine?
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1.5
What will we discuss in this course?
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2. Ancestry
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2.1
How did different human populations form?
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2.2
How many present-day individuals are recently admixed?
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2.3
What is global vs. local ancestry?
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2.4
How do we quantify global ancestry?
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2.5
How do we analyze local ancestry?
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3. Complex Variants
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3.1
What exactly is a "genome"?
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3.2
How can genomes vary?
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3.3
What are the types of repetitive DNA?
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3.4
Why are human leukocyte antigen (HLA) regions important?
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3.5
How do complex variants affect disease risk?
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4. Predicting Risk from Genomes
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4.1
What is a polygenic risk score?
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4.2
How well do current Polygenic Risk Scores perform?
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4.3
How do we develop broadly-relevant Polygenic Risk Scores?
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5. Social Determinants of Health
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5.1
How can we communicate about social determinants of health?
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6. Building Disease Risk Models Across Biobanks
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6.1
How can we ensure the privacy and security of genomic data?
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6.2
How can we minimize privacy risk when linking biomedical data?
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7. Integrating Local Ancestry into Disease Risk Models
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7.1
How can we simulate and analyze haplotype data?
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8. Conclusion
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8.1
NAME TBD
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9. OLD MATERIALS
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9.1
What is DNA sequencing?
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9.2
How do we detect mutations?
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9.3
How do we find disease-associated genetic variants?
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9.4
How can we integrate genotypes inferred by different tools?
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